Quranic manuscripts constitute a fundamental part of the cultural and religious heritage of the Islamic world and occupy a central position in Quranic studies. Many of these manuscripts, however, have been exposed to the risk of damage or loss due to wars, environmental factors, and historical neglect. Within this context, Orientalist scholars have played an influential role in the discovery, preservation, and scholarly examination of Quranic manuscripts. At the same time, their activities have generated sustained debate and critical evaluation. While their efforts have significantly contributed to the preservation and accessibility of Quranic heritage, their methodological approaches to the Quran as a historical and cultural text have at times conflicted with Islamic theological perspectives. This article critically examines the role of Orientalists in the revival of Quranic manuscripts and their impact on the development of codicological studies. Using a descriptive-analytical method based on library and archival sources, the study evaluates both the achievements and the challenges associated with Orientalist activities in this field. The findings demonstrate that Orientalists have made substantial contributions through the identification of important manuscripts, such as the Sana’a manuscripts, and through major digitization initiatives.